A Review of A Textbook of Medicinal Chemistry Synthetic & Biochemical Approch Volume 2 by Surendra N Pandeya
Medicinal chemistry is a branch of chemistry that deals with the design, synthesis and evaluation of drugs for various diseases. It is an interdisciplinary field that requires knowledge of organic chemistry, biochemistry, pharmacology and molecular biology. A Textbook of Medicinal Chemistry Synthetic & Biochemical Approch Volume 2 by Surendra N Pandeya is a comprehensive book that covers the fundamental concepts and applications of medicinal chemistry in a clear and systematic manner.
The book is divided into two parts: Part A covers the synthetic aspects of medicinal chemistry, such as drug design strategies, stereochemistry, combinatorial chemistry, prodrugs and drug delivery systems. Part B covers the biochemical aspects of medicinal chemistry, such as enzyme inhibitors, receptor agonists and antagonists, hormones and neurotransmitters, nucleic acids and anticancer agents. The book also includes chapters on pharmacokinetics, pharmacodynamics, drug metabolism and drug interactions.
The book is written in a simple and lucid language, with numerous examples, diagrams, tables and figures to illustrate the concepts. The book also provides review questions, exercises and references at the end of each chapter to test the understanding of the readers. The book is suitable for undergraduate and postgraduate students of pharmacy, chemistry and related disciplines, as well as for researchers and professionals in the field of medicinal chemistry.
A Textbook of Medicinal Chemistry Synthetic & Biochemical Approch Volume 2 by Surendra N Pandeya is a valuable resource for anyone who wants to learn about the principles and practice of medicinal chemistry. The book is available on Amazon.in[^1^] and other online platforms.
In this article, we will review some of the key topics and concepts covered in the book. We will also highlight some of the advantages and limitations of the book, as well as some of the suggestions for improvement.
Synthetic Aspects of Medicinal Chemistry
Part A of the book deals with the synthetic aspects of medicinal chemistry, which involve the design and synthesis of new compounds with desired biological activities. The book covers various drug design strategies, such as structure-activity relationship (SAR), quantitative structure-activity relationship (QSAR), molecular modelling, pharmacophore mapping and computer-aided drug design (CADD). The book also explains the importance of stereochemistry in drug action and synthesis, and the methods to control and manipulate stereochemistry. The book also discusses the principles and applications of combinatorial chemistry, which is a technique to generate large libraries of compounds for screening. The book also covers the concept and types of prodrugs, which are inactive derivatives of drugs that are converted to active forms in the body. The book also describes various drug delivery systems, such as liposomes, nanoparticles, micelles and polymers, that can enhance the efficacy and safety of drugs.
The book provides a good overview of the synthetic aspects of medicinal chemistry, with relevant examples and case studies. The book also provides practical tips and guidelines for designing and synthesizing new compounds. However, the book could have included more details on some topics, such as molecular modelling, CADD and combinatorial chemistry, as these are rapidly evolving fields that require more in-depth knowledge. The book could have also included more exercises and problems to test the application skills of the readers.
Biochemical Aspects of Medicinal Chemistry
Part B of the book deals with the biochemical aspects of medicinal chemistry, which involve the interaction of drugs with biological targets, such as enzymes, receptors, hormones and nucleic acids. The book covers various types of enzyme inhibitors, such as reversible, irreversible and transition state analogs, and their mechanisms of action. The book also covers various types of receptor agonists and antagonists, such as full, partial and inverse agonists, competitive and non-competitive antagonists, and their effects on receptor function. The book also discusses various classes of hormones and neurotransmitters, such as steroids, peptides, catecholamines and serotonin, and their roles in regulating physiological processes. The book also describes various types of nucleic acids and anticancer agents, such as DNA intercalators, alkylating agents, antimetabolites and topoisomerase inhibitors, and their modes of action.
The book provides a comprehensive coverage of the biochemical aspects of medicinal chemistry, with clear explanations and diagrams. The book also provides relevant examples and applications of various drugs that act on different biological targets. However, the book could have included more details on some topics, such as receptor subtypes, signal transduction pathways and gene therapy. The book could have also included more recent developments and advances in the field of biochemical medicinal chemistry.
Pharmacokinetics, Pharmacodynamics, Drug Metabolism and Drug Interactions
The book also includes chapters on pharmacokinetics, pharmacodynamics, drug metabolism and drug interactions. Pharmacokinetics is the study of how drugs are absorbed,